Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 9/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22712556 | 0.89 | DGAT1 (0.59) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL29367270 | 0.89 | DGAT1 (0.59) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL22086013 | 0.87 | DGAT1 (0.60) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL28507142 | 0.83 | DGAT1 (0.55) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL2066133 | 0.82 | DGAT1 (0.56) | DGAT1FFAR1LPLLIPGCA1 | |
| SCHEMBL25475421 | 0.81 | DGAT1 (0.55) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL1284745 | 0.81 | DGAT1 (0.58) | DGAT1FFAR1LPLLIPGCA1 | |
| SCHEMBL14863340 | 0.81 | CA1 (0.49) | DGAT1AAK1LPLLIPGCA1 | |
| SCHEMBL16787846 | 0.81 | DGAT1 (0.69) | DGAT1AAK1FFAR1LPLLIPG | |
| SCHEMBL1284321 | 0.81 | DGAT1 (0.55) | DGAT1FFAR1LPLLIPGCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294811-A2 | SMALL MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF ALS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3350180-A1 | 8-[6-[3-(AMINO)PROPOXY]-3-PYRIDYL]-1 -ISOPROPYL-IMIDAZO[4,5-C]QUINOLIN-2-ONE DERIVATIVES AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017046216-A1 | 8-[6-[3-(AMINO)PROPOXY]-3-PYRIDYL]-1 -ISOPROPYL-IMIDAZO[4,5-C]QUINOLIN-2-ONE DERIVATIVES AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2017-03-23 | — | — | WO | disclosed |
| EP-3140303-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2017-03-15 | — | — | EP | disclosed |
| WO-2015170081-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2015-11-12 | — | — | WO | disclosed |
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |