Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285235 | 0.84 | CCNE2 (0.40) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL1694708 | 0.70 | KDM4E (0.44) | JAK2ROCK2PRKCDROCK1NUDT1 | |
| SCHEMBL29705507 | 0.70 | KDM4E (0.44) | JAK2ROCK2PRKCDROCK1NUDT1 | |
| SCHEMBL9937393 | 0.70 | PRKCQ (0.43) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL16897064 | 0.66 | PIK3CD (0.41) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL1694892 | 0.66 | RET (0.46) | ROCK1NUDT1CCNE2CCNE1CDK2 | |
| SCHEMBL13075987 | 0.66 | PIK3CD (0.41) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL29499046 | 0.66 | RET (0.46) | ROCK1NUDT1CCNE2CCNE1CDK2 | |
| SCHEMBL16897010 | 0.66 | XDH (0.42) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| Hydrochloric Acid SCHEMBL16897145 | 0.65 | XDH (0.41) | PRKCQJAK2ROCK2PRKCDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |