Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 5/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285076 | 0.84 | PRKCQ (0.38) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL29705507 | 0.77 | KDM4E (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL1694708 | 0.77 | KDM4E (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL1695143 | 0.72 | ROCK2 (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL1694892 | 0.72 | RET (0.46) | CCNE2CCNE1CDK2ROCK1AURKA | |
| SCHEMBL29499046 | 0.72 | RET (0.46) | CCNE2CCNE1CDK2ROCK1AURKA | |
| SCHEMBL30989267 | 0.70 | TSHR (0.50) | CCNE2CCNE1CDK2NUDT1 | |
| SCHEMBL9937393 | 0.70 | PRKCQ (0.43) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL15532940 | 0.70 | TSHR (0.50) | CCNE2CCNE1CDK2NUDT1 | |
| SCHEMBL4768894 | 0.69 | AURKA (0.57) | CCNE2CCNE1CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |