Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28507827 | 0.88 | CA1 (0.62) | CA2CA1GABRR1KMT2ABIRC2 | |
| SCHEMBL6617648 | 0.83 | CA2 (0.60) | CA2MAPK1CHRM1AKR1A1CHRM3 | |
| SCHEMBL14407715 | 0.82 | SLC1A1 (0.48) | CA2CA1MAPK1CHRM1AKR1A1 | |
| SCHEMBL7105090 | 0.81 | SMN1; SMN2 (0.46) | CA2CA1GABRR1CYP1A2KMT2A | |
| SCHEMBL27705382 | 0.80 | CA2 (0.48) | CA2CA1MAPK1CHRM1AKR1A1 | |
| SCHEMBL17753385 | 0.79 | CA2 (0.47) | CA2CA1MAPK1CHRM1AKR1A1 | |
| SCHEMBL17616867 | 0.78 | CA2 (0.50) | CA2CA1MAPK1SLC1A1SLC1A3 | |
| SCHEMBL125406 | 0.78 | CA2 (0.71) | CA2CA1MAPK1CHRM1AKR1A1 | |
| SCHEMBL19248924 | 0.78 | CA2 (0.46) | CA2CA1MAPK1SLC1A1SLC1A3 | |
| SCHEMBL14701895 | 0.78 | CA1 (0.44) | CA2CA1GABRR1CYP1A2ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-112189008-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-01-05 | — | — | CN | disclosed |