Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 6/20 | 0.67 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513904 | 0.84 | CHKA (0.66) | CHKAALKLSS | |
| SCHEMBL12126812 | 0.81 | CHKA (0.79) | CHKASIGMAR1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16121662 | 0.80 | CHKA (1.00) | CHKAMAP3K11SIGMAR1KDM4E | |
| SCHEMBL6152523 | 0.78 | KDM4E (0.50) | ABCB1ALDH1A1SMN1; SMN2NPC1TP53 | |
| SCHEMBL28511571 | 0.78 | CHKA (0.54) | CHKA | |
| SCHEMBL28506231 | 0.77 | CHKA (0.50) | CHKAMAP3K11MAP4K1INSRALK | |
| SCHEMBL12066038 | 0.75 | MAP3K11 (1.00) | MAP3K11MAP4K1INSR | |
| SCHEMBL19285228 | 0.75 | SIGMAR1 (0.85) | CHKASIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1043952 | 0.75 | SIGMAR1 (0.85) | CHKASIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20804352 | 0.75 | SIGMAR1 (0.85) | CHKASIGMAR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |