Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 10/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 3/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511435 | 0.89 | SIGMAR1 (0.48) | CHKA | |
| SCHEMBL28513904 | 0.79 | CHKA (0.66) | CHKALMNATNKSPARP1TNIK | |
| SCHEMBL28499871 | 0.78 | MELK (0.49) | CHKA | |
| SCHEMBL28508659 | 0.78 | CHKA (0.67) | CHKA | |
| SCHEMBL578497 | 0.77 | LMNA (0.67) | CHKALMNAMC4RHDAC6CA2 | |
| SCHEMBL28499872 | 0.75 | CHKA (0.58) | CHKALMNATNKSPARP1MC4R | |
| SCHEMBL28513456 | 0.74 | SIGMAR1 (0.47) | CHKA | |
| SCHEMBL28499941 | 0.71 | MAP4K1 (0.40) | LMNA | |
| SCHEMBL16095812 | 0.71 | CHKA (0.75) | CHKALMNAMC4RCA2NCF1 | |
| SCHEMBL3687427 | 0.71 | CHKA (0.87) | CHKALMNAMC4RTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |