Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502461 | 0.89 | MAPK1 (0.50) | MAPK1RIPK1RPS6KA3MAP4K1KDM4E | |
| SCHEMBL28503440 | 0.84 | MAPK1 (0.54) | MAPK1RIPK1RPS6KA3MAP4K1DYRK1A | |
| SCHEMBL28513749 | 0.83 | MAPK1 (0.54) | MAPK1RIPK1MAP4K1NPC1DYRK1A | |
| SCHEMBL30641871 | 0.83 | MAPK1 (0.54) | MAPK1RIPK1MAP4K1NPC1DYRK1A | |
| SCHEMBL28510087 | 0.81 | MAP3K11 (0.55) | MAPK1RIPK1FLT3 | |
| SCHEMBL28504401 | 0.81 | MAPK1 (0.55) | MAPK1RIPK1DYRK1A | |
| SCHEMBL28513878 | 0.81 | MAPK1 (0.50) | MAPK1RIPK1 | |
| SCHEMBL28905280 | 0.79 | MAPK1 (0.53) | MAPK1RIPK1MAPTRAB9ADYRK1A | |
| SCHEMBL28514963 | 0.79 | MAPK1 (0.53) | MAPK1RIPK1MAPTRAB9ADYRK1A | |
| SCHEMBL28499630 | 0.78 | FLT3 (0.56) | RIPK1RPS6KA3MAP4K1DYRK1ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |