Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.55 |
| ▸ | IKBKB | O14920 | 2/20 | 0.55 |
| ▸ | CHUK | O15111 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15171446 | 0.83 | MAP3K11 (0.58) | MAP3K11MAPK1IKBKBCHUKABL1 | |
| SCHEMBL28508679 | 0.81 | MAPK1 (0.59) | MAPK1FLT3RIPK1 | |
| SCHEMBL15154791 | 0.80 | MAP3K11 (0.80) | MAP3K11MAPK1IKBKBCHUKABL1 | |
| SCHEMBL28506193 | 0.78 | TNIK (0.53) | MAP3K11MAPK1IKBKBCHUKABL1 | |
| SCHEMBL18197658 | 0.76 | MAP3K11 (0.73) | MAP3K11MAPK1IKBKBCHUKABL1 | |
| SCHEMBL28513749 | 0.75 | MAPK1 (0.54) | MAPK1RIPK1 | |
| SCHEMBL30641871 | 0.75 | MAPK1 (0.54) | MAPK1RIPK1 | |
| SCHEMBL28769143 | 0.75 | MAPK1 (0.56) | MAPK1FLT3RIPK1SYKAURKB | |
| SCHEMBL29888818 | 0.75 | MAPK1 (0.56) | MAPK1FLT3RIPK1SYKAURKB | |
| SCHEMBL7874293 | 0.75 | MAP3K11 (0.61) | MAP3K11MAPK1IKBKBCHUKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |