Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 13/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30641871 | 1.00 | MAPK1 (0.54) | MAPK1DYRK1ARIPK1PIK3CDPIK3R1 | |
| SCHEMBL28504401 | 0.87 | MAPK1 (0.55) | MAPK1DYRK1ARIPK1PIK3CDPIK3R1 | |
| SCHEMBL28513876 | 0.85 | MAPK1 (0.55) | MAPK1DYRK1ARIPK1MAP4K1 | |
| SCHEMBL28514903 | 0.85 | MAPK1 (0.51) | MAPK1DYRK1ARIPK1JAK2JAK3 | |
| SCHEMBL28508679 | 0.83 | MAPK1 (0.59) | MAPK1DYRK1ARIPK1MAP4K1NPC1 | |
| SCHEMBL28506118 | 0.82 | DYRK1A (0.51) | MAPK1DYRK1ARIPK1PIK3CDPIK3CA | |
| SCHEMBL28507472 | 0.79 | MAP4K1 (0.49) | MAPK1MAP4K1JAK2JAK3 | |
| SCHEMBL28507725 | 0.78 | RPS6KA3 (0.52) | MAPK1MAP4K1JAK1 | |
| SCHEMBL28513565 | 0.77 | MAPK1 (0.53) | MAPK1DYRK1ARIPK1PIK3CDPIK3R1 | |
| SCHEMBL22858967 | 0.76 | PIK3CD (0.52) | MAPK1DYRK1ARIPK1PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |