Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.53 |
| ▸ | PPARG | P37231 | 3/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882354 | 0.89 | NPC1 (0.49) | NR1H4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2857034 | 0.88 | KDM4E (0.62) | NR1H4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL13513708 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1BRAFMAPTPOLB | |
| SCHEMBL2852818 | 0.87 | NPC1 (0.50) | NR1H4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2853811 | 0.86 | SMN1; SMN2 (0.60) | ALDH1A1NPC1RAB9ABRAFMAPT | |
| SCHEMBL14539344 | 0.86 | KDM4E (0.52) | NR1H4KDM4EALDH1A1BRAFMAPT | |
| SCHEMBL13513752 | 0.85 | BRAF (0.49) | NR1H4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2850859 | 0.84 | KEAP1 (0.51) | NR1H4KDM4EALDH1A1BRAFMAPT | |
| SCHEMBL2852325 | 0.84 | KEAP1 (0.51) | NR1H4KDM4EALDH1A1BRAFMAPT | |
| SCHEMBL13513684 | 0.83 | CCR1 (0.54) | NR1H4KDM4EALDH1A1BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |