Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850032 | 0.91 | NPC1 (0.56) | NPC1RAB9AMAPTNR1H4KDM4E | |
| SCHEMBL13513708 | 0.88 | KDM4E (0.53) | MAPTKDM4EALDH1A1BRAFMALT1 | |
| SCHEMBL2857034 | 0.87 | KDM4E (0.62) | NPC1RAB9AMAPTNR1H4KDM4E | |
| SCHEMBL2850892 | 0.87 | NR1H4 (0.53) | NPC1RAB9AMAPTNR1H4KDM4E | |
| SCHEMBL14539344 | 0.87 | KDM4E (0.52) | MAPTNR1H4KDM4EALDH1A1BRAF | |
| SCHEMBL13513684 | 0.86 | CCR1 (0.54) | MAPTNR1H4KDM4EALDH1A1CCR1 | |
| SCHEMBL13513752 | 0.86 | BRAF (0.49) | NPC1RAB9AMAPTNR1H4KDM4E | |
| SCHEMBL14539343 | 0.85 | NR1H4 (0.47) | MAPTNR1H4KDM4EALDH1A1CCR1 | |
| SCHEMBL2850859 | 0.85 | KEAP1 (0.51) | MAPTNR1H4KDM4EALDH1A1BRAF | |
| SCHEMBL2852325 | 0.85 | KEAP1 (0.51) | MAPTNR1H4KDM4EALDH1A1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |