Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28517495 | 0.89 | MAPT (0.46) | ALDH1A1MAPTKDM4EGAAHCAR3 | |
| SCHEMBL29200576 | 0.89 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL28510943 | 0.86 | MAPT (0.46) | ALDH1A1MAPTGAAHCAR3PTGER4 | |
| SCHEMBL28606480 | 0.84 | ALDH1A1 (0.37) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL28606477 | 0.84 | ALDH1A1 (0.37) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL28906815 | 0.84 | PTGER4 (0.45) | ALDH1A1KDM4EPTGER4PRSS1 | |
| SCHEMBL28905708 | 0.82 | KDM4E (0.58) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL19451570 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4EGAAHTT | |
| Hydrochloric Acid SCHEMBL28597064 | 0.81 | PRSS1 (0.39) | ALDH1A1MAPTKDM4EGAAHTT | |
| Hydrochloric Acid SCHEMBL28597062 | 0.81 | PRSS1 (0.39) | ALDH1A1MAPTKDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279835-B | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-112279835-A | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2021-01-29 | — | — | CN | disclosed |