Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28510943 | 0.97 | MAPT (0.46) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL28509702 | 0.89 | ALDH1A1 (0.43) | MAPTGAAALDH1A1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28542838 | 0.85 | MAPT (0.47) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL29200491 | 0.85 | LMNA (0.47) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19437401 | 0.85 | MAPT (0.51) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19436434 | 0.84 | MAPT (0.49) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19436435 | 0.84 | MAPT (0.49) | MAPTGAASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL28508495 | 0.82 | PTGER4 (0.40) | GAASMN1; SMN2ALDH1A1L3MBTL1PTGER4 | |
| SCHEMBL28419831 | 0.81 | MAPT (0.42) | MAPTSMN1; SMN2ALDH1A1TDP1RAB9A | |
| SCHEMBL28419832 | 0.81 | MAPT (0.42) | MAPTSMN1; SMN2ALDH1A1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279835-B | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-112279835-A | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2021-01-29 | — | — | CN | disclosed |