Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28497293 | 0.82 | ALDH1A1 (0.30) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28506664 | 0.79 | ALDH1A1 (0.31) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28500777 | 0.77 | ALDH1A1 (0.30) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28506639 | 0.77 | TYMP (0.33) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28516302 | 0.76 | KCNMA1 (0.31) | — | |
| SCHEMBL28506621 | 0.76 | PDE3B (0.30) | — | |
| SCHEMBL28500717 | 0.75 | MAPT (0.39) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28538572 | 0.74 | — | — | |
| SCHEMBL28516270 | 0.73 | — | — | |
| SCHEMBL28505472 | 0.70 | ALDH1A1 (0.38) | ALDH1A1GAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409378-A | Tricyclic PI3K inhibitor compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-108349996-B | Tricyclic PI3K inhibitor compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-01-08 | — | — | CN | disclosed |