Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274084 | 0.87 | HSD11B1 (0.40) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL21274289 | 0.84 | GPR119 (0.45) | GPR119RXFP1TP53PARP1JAK2 | |
| SCHEMBL21274501 | 0.83 | GPR119 (0.42) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL22801948 | 0.83 | GPR119 (0.42) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL21274032 | 0.83 | GPR119 (0.44) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL21274200 | 0.83 | GPR119 (0.42) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL21274366 | 0.82 | GPR119 (0.43) | GPR119RXFP1TP53PARP1MEN1 | |
| SCHEMBL21274013 | 0.82 | GPR119 (0.41) | GPR119HSD11B1AKR1C3RXFP1TP53 | |
| SCHEMBL21273934 | 0.82 | GPR119 (0.43) | GPR119RXFP1TP53PARP1MEN1 | |
| SCHEMBL21274376 | 0.82 | GPR119 (0.43) | GPR119HSD11B1AKR1C3RXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112105357-A | Pharmaceutically acceptable 6,5 heterobicyclic derivatives | UCB生物制药有限责任公司 | 2020-12-18 | — | — | CN | claimed |
| CN-112105357-A | Pharmaceutically acceptable 6,5 heterobicyclic derivatives | UCB生物制药有限责任公司 | 2020-12-18 | — | — | CN | disclosed |