Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28512170 | 0.81 | EPHX2 (0.37) | DPP4DPP8EPHX2LTA4HNAMPT | |
| Trifluoroacetic Acid SCHEMBL30557635 | 0.76 | DPP4 (0.54) | DPP4DPP8NAMPTPARP1SCN9A | |
| Trifluoroacetic Acid SCHEMBL4154691 | 0.69 | HDAC6 (0.55) | DPP4DPP8EPHX2NAMPTPARP1 | |
| SCHEMBL30980046 | 0.68 | NAMPT (0.49) | DPP4DPP8NAMPTPDPK1PARP1 | |
| SCHEMBL22330363 | 0.66 | P2RX7 (0.44) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL28510185 | 0.65 | HSD17B10 (0.42) | — | |
| SCHEMBL22977583 | 0.64 | DPP4 (0.49) | DPP4DPP8NAMPTPDPK1PARP1 | |
| SCHEMBL12208897 | 0.64 | NAMPT (0.45) | DPP4DPP8NAMPTPDPK1PARP1 | |
| Trifluoroacetic Acid SCHEMBL28509604 | 0.64 | SMN1; SMN2 (0.46) | SCN9A | |
| Trifluoroacetic Acid SCHEMBL7344714 | 0.64 | GAA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279848-A | Pan-JAKs inhibitor and application thereof | 四川海思科制药有限公司 | 2021-01-29 | — | — | CN | disclosed |