Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.47 |
| ▸ | CDK9 | P50750 | 7/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30507263 | 1.00 | ADRA1D (0.54) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL28512819 | 0.78 | MAP3K14 (0.52) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL30507251 | 0.78 | MAP3K14 (0.52) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL3103196 | 0.77 | PRKACA (0.56) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL28505700 | 0.77 | ADRA1D (0.65) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL30046927 | 0.77 | HSP90AA1 (0.60) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL18130895 | 0.77 | HSP90AA1 (0.60) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL1914955 | 0.74 | HSP90AA1 (0.59) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL5140478 | 0.74 | FEN1 (0.57) | ADRA1DADRA1AHSP90AA1AURKAPRKACA | |
| SCHEMBL30353577 | 0.74 | FEN1 (0.57) | ADRA1DADRA1AHSP90AA1AURKAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010844-B | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | disclosed |