Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2989087 | 0.83 | KMO (0.61) | HSP90AA1DYRK1AAURKAPRKACAADORA2A | |
| SCHEMBL13977721 | 0.82 | JAK2 (0.60) | HSP90AA1HSP90AB1DYRK1AAURKAPRKACA | |
| SCHEMBL29002136 | 0.81 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1DYRK1AADORA2AJAK2 | |
| SCHEMBL30046927 | 0.81 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1DYRK1AAURKAPRKACA | |
| SCHEMBL447060 | 0.81 | CYP19A1 (0.47) | HSP90AA1HSP90AB1DYRK1AJAK2KMO | |
| SCHEMBL10940020 | 0.81 | CYP19A1 (0.56) | HSP90AA1HSP90AB1KMOMAPTL3MBTL1 | |
| SCHEMBL18130895 | 0.81 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1DYRK1AAURKAPRKACA | |
| SCHEMBL503736 | 0.80 | CDK5 (0.53) | HSP90AA1HSP90AB1DYRK1AAURKAPRKACA | |
| SCHEMBL4738230 | 0.80 | CCNT1 (0.60) | HSP90AA1DYRK1AAURKAPRKACAADORA2A | |
| SCHEMBL29548754 | 0.80 | CCNT1 (0.60) | HSP90AA1DYRK1AAURKAPRKACAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230477-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS | EUROSCREEN S.A. (BE) | 2011-09-22 | — | — | US | disclosed |
| EP-2364297-A1 | Compounds, pharmaceutical composition and methods for use in treating metabolic disorders | Euroscreen S.A. (BE) | 2011-09-14 | — | — | EP | disclosed |
| WO-2011076734-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES | EUROSCREEN S.A. (BE) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011076732-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS | EUROSCREEN S.A. (BE) | 2011-06-30 | — | — | WO | disclosed |
| WO-2010066682-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS | EUROSCREEN S.A. (BE) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230477-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS | CPT1A, LIPC, PC | HSP90AA1 3333/4885HSP90AB1 3279/4885DYRK1A 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.