Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049741 | 0.90 | HTT (0.59) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL17495253 | 0.89 | HTT (0.56) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL5574078 | 0.89 | SYK (0.57) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6932926 | 0.88 | ALDH1A1 (0.53) | HTTLMNASMN1; SMN2SYKMAPT | |
| SCHEMBL25908037 | 0.88 | ALDH1A1 (0.53) | HTTLMNASMN1; SMN2SYKMAPT | |
| SCHEMBL6016839 | 0.88 | SYK (0.57) | HTTLMNASMN1; SMN2SYKMAPT | |
| SCHEMBL11927647 | 0.88 | HTT (0.49) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7995256 | 0.86 | HTT (0.50) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3712595 | 0.86 | HTT (0.56) | HTTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL25372019 | 0.85 | LMNA (0.62) | HTTMEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112272669-A | Cross-linked pyrrolobenzodiazepine dimer (PBD) derivatives and conjugates thereof | 杭州多禧生物科技有限公司 | 2021-01-26 | — | — | CN | disclosed |