Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL31412690 | 0.98 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL27674763 | 0.98 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL4226809 | 0.98 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL19691965 | 0.98 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL10423685 | 0.94 | LMNA (0.41) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL25263022 | 0.90 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL16234821 | 0.90 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL7715623 | 0.90 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL27827379 | 0.90 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL25263020 | 0.90 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112250057-A | Preparation method of ammonium nitrate-assisted macroporous thin-layer carbon | 山东理工大学 | 2021-01-22 | — | — | CN | disclosed |