Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851357 | 1.00 | HSPB1 (0.58) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL23797981 | 0.90 | HSPB1 (0.55) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2862000 | 0.84 | HSPB1 (0.60) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2862003 | 0.84 | HSPB1 (0.60) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2857491 | 0.81 | HSPB1 (0.54) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2857489 | 0.81 | HSPB1 (0.54) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2852227 | 0.81 | KDM4E (0.52) | RAB9AKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL1290970 | 0.81 | HSPB1 (0.63) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL1290972 | 0.81 | HSPB1 (0.63) | HSPB1PPARGMAPTNPSR1RAB9A | |
| SCHEMBL2859667 | 0.80 | HSPB1 (0.57) | HSPB1PPARGMAPTNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2399921-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-08-12 | — | — | EP | disclosed |
| US-8697874-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-15 | — | — | US | disclosed |
| EP-2399921-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-12-28 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |