Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30668855 | 0.91 | KDM4E (0.54) | KDM4EKDM4DCYP2C19MEN1CYP1A2 | |
| SCHEMBL2896934 | 0.82 | KDM4E (0.39) | KDM4E | |
| SCHEMBL1831348 | 0.74 | KDM4E (0.38) | KDM4E | |
| SCHEMBL285259 | 0.72 | CYP17A1 (0.35) | KDM4ECYP1A2CYP11B1CYP11B2 | |
| SCHEMBL1922695 | 0.71 | TLR7 (0.36) | KDM4EMEN1KMT2A | |
| SCHEMBL18113677 | 0.71 | NR3C1 (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL16291963 | 0.71 | KDM4E (0.50) | KDM4EKDM4DCYP2C19MEN1CYP1A2 | |
| SCHEMBL12775617 | 0.71 | KDM4E (0.50) | KDM4EKDM4DCYP2C19MEN1CYP1A2 | |
| SCHEMBL30554368 | 0.69 | RECQL (0.44) | KDM4EMEN1CYP1A2KMT2ACYP11B1 | |
| SCHEMBL18113496 | 0.69 | RECQL (0.44) | KDM4EMEN1CYP1A2KMT2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |