Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18113496 | 1.00 | RECQL (0.44) | RECQLKMOCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL31540114 | 0.82 | CYP11B1 (0.39) | RECQLCYP11B1CYP11B2CYP1A2ADRA2A | |
| SCHEMBL23901367 | 0.80 | HDAC8 (0.41) | KMOCYP11B1CYP11B2MEN1LMNA | |
| SCHEMBL18113677 | 0.80 | NR3C1 (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL20401326 | 0.80 | ACSS2 (0.39) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL9959744 | 0.77 | ACSS2 (0.43) | KDM4EALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL29820308 | 0.76 | CYP2A6 (0.39) | KMOKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL12074315 | 0.76 | HDAC8 (0.36) | RECQL | |
| SCHEMBL10050859 | 0.76 | RECQL (0.43) | RECQLKMOCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL30449976 | 0.76 | RECQL (0.43) | RECQLKMOCYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024158745-A1 | INHIBITORS OF LRRK2 | VANDERBILT UNIVERSITY (US) | 2024-08-02 | — | — | WO | disclosed |
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |