Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Mepanipyrim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | OGG1 | O15527 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mepanipyrim SCHEMBL22040 | 0.93 | TAAR1 (0.55) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL29672635 | 0.93 | TAAR1 (0.55) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL28756483 | 0.92 | TAAR1 (0.54) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL9795913 | 0.91 | TAAR1 (0.48) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL26109940 | 0.86 | TAAR1 (0.49) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL18132072 | 0.81 | TAAR1 (0.44) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| Mepanipyrim SCHEMBL5182844 | 0.80 | SMN1; SMN2 (0.43) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| SCHEMBL9763442 | 0.79 | KCNH3 (0.44) | RAB9ANPC1SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL9795987 | 0.78 | TAAR1 (0.51) | RAB9ANPC1SLC2A1SMN1; SMN2TAAR1 | |
| SCHEMBL9795701 | 0.77 | MAPT (0.49) | RAB9ANPC1SMN1; SMN2TAAR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112205409-A | Kasugamycin and Xinjunan compound water aqua and preparation method thereof | 陕西麦可罗生物科技有限公司 | 2021-01-12 | — | — | CN | disclosed |