Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317962 | 0.82 | MAPT (0.69) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL28506875 | 0.82 | MAPT (0.69) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL13568970 | 0.81 | KMT2A (0.54) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL28515481 | 0.81 | IKBKB (0.66) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL28521624 | 0.80 | MAPT (0.74) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL14417610 | 0.80 | MAPT (0.68) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL3970964 | 0.80 | MAPT (0.68) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL3970958 | 0.80 | MAPT (0.68) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL23209627 | 0.79 | MAPT (0.61) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL23209629 | 0.79 | MAPT (0.61) | MAPTSMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079744-A | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2020-12-15 | — | — | CN | claimed |
| CN-112079744-B | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2021-07-30 | — | — | CN | disclosed |
| CN-112079744-A | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2020-12-15 | — | — | CN | disclosed |