Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.52 |
| ▸ | RARA | P10276 | 2/20 | 0.52 |
| ▸ | RARG | P13631 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 3/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814690 | 0.92 | PPARA (0.55) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL2853148 | 0.91 | HIF1A (0.43) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL5598223 | 0.89 | PLK1 (0.50) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL1810486 | 0.84 | PPARA (0.46) | PLK1PTPN11PTPROPPARASTING1 | |
| SCHEMBL5598090 | 0.84 | PLK1 (0.47) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL2858458 | 0.82 | RARB (0.57) | RARBRARAPLK1PTPN11ALDH1A1 | |
| SCHEMBL5598480 | 0.81 | PLK1 (0.45) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL5598384 | 0.80 | PLK1 (0.54) | RARBRARARARGPLK1PTPN11 | |
| SCHEMBL2853174 | 0.79 | PLK1 (0.51) | RARBRARAPLK1PTPN11PTPRO | |
| SCHEMBL5598402 | 0.77 | RARB (0.54) | RARBRARARARGPLK1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | claimed |