Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.51 |
| ▸ | RARB | P10826 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850975 | 0.87 | ALOX15 (0.43) | PLK1HDAC1HDAC8HDAC6PTPN11 | |
| SCHEMBL2858458 | 0.81 | RARB (0.57) | PLK1RARBHDAC1PTPN11MEN1 | |
| SCHEMBL1814690 | 0.80 | PPARA (0.55) | PLK1RARBPTPN11PTPROALDH1A1 | |
| SCHEMBL2858924 | 0.80 | RARB (0.61) | PLK1RARBMEN1ALDH1A1RARA | |
| SCHEMBL1811178 | 0.79 | RARB (0.73) | PLK1RARBPTPN11PTPROMEN1 | |
| SCHEMBL2851976 | 0.79 | RARB (0.52) | PLK1RARBPTPN11PTPROALDH1A1 | |
| SCHEMBL2402922 | 0.78 | RARB (0.71) | PLK1RARBPTPN11PTPROMEN1 | |
| SCHEMBL5598384 | 0.77 | PLK1 (0.54) | PLK1RARBPTPN11PTPROPLK3 | |
| SCHEMBL13513422 | 0.77 | HDAC8 (0.49) | PLK1RARBHDAC1HDAC8HDAC6 | |
| SCHEMBL5598480 | 0.76 | PLK1 (0.45) | PLK1RARBPTPN11PTPROALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | claimed |