Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409512 | 0.98 | LMNA (0.41) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Fluoride Ion SCHEMBL28520178 | 0.96 | LMNA (0.40) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Bromide SCHEMBL28909148 | 0.96 | LMNA (0.40) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Iodide SCHEMBL28519463 | 0.96 | LMNA (0.40) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| SCHEMBL1082818 | 0.81 | NPC1 (0.39) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9696543 | 0.76 | KDM4E (0.43) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL4053164 | 0.75 | TAAR1 (0.41) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| SCHEMBL5711144 | 0.74 | KDM4E (0.41) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL20191168 | 0.74 | TP53 (0.43) | LMNAKDM4EALDH1A1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL28388643 | 0.74 | KDM4E (0.37) | LMNAKDM4EALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107427869-B | Heavy metal fixing agent for treating ash and method for treating ash using same | 栗田工业株式会社 | 2021-02-02 | — | — | CN | disclosed |