Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765637 | 0.91 | AR (0.43) | ARPLA2G7L3MBTL1POLBPTPN7 | |
| SCHEMBL13165638 | 0.90 | EPHX2 (0.40) | L3MBTL1MAPTKMT2APOLBPTPN7 | |
| SCHEMBL3722055 | 0.90 | P2RX7 (0.35) | ARPLA2G7KMT2AEPHX2P2RX7 | |
| SCHEMBL13165629 | 0.90 | L3MBTL1 (0.39) | L3MBTL1MAPTKMT2APOLBPTPN7 | |
| SCHEMBL13166048 | 0.90 | L3MBTL1 (0.39) | L3MBTL1MAPTKMT2APOLBPTPN7 | |
| SCHEMBL13165640 | 0.88 | L3MBTL1 (0.41) | PLA2G7L3MBTL1MAPTKMT2APOLB | |
| SCHEMBL13165643 | 0.88 | L3MBTL1 (0.38) | L3MBTL1MAPTKMT2APOLBPTPN7 | |
| SCHEMBL13166054 | 0.87 | CNR1 (0.37) | L3MBTL1MAPTKMT2AEPHX2GAA | |
| SCHEMBL13166051 | 0.87 | OPRL1 (0.38) | L3MBTL1MAPTKMT2APOLBPTPN7 | |
| SCHEMBL13165631 | 0.87 | L3MBTL1 (0.37) | L3MBTL1MAPTKMT2APOLBPTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |