Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490990 | 0.86 | ALOX5 (0.69) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL3756959 | 0.84 | ALOX5 (0.71) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL4005549 | 0.83 | ALOX5 (0.86) | ALOX5NFKB1OR51E2LTA4HCYP1A2 | |
| SCHEMBL20940489 | 0.83 | ALOX5 (1.00) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL10879308 | 0.83 | ALOX5 (0.66) | ALOX5OR51E2CA12CA1CA2 | |
| SCHEMBL13055954 | 0.82 | ALOX5 (0.59) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL490925 | 0.81 | ALOX5 (0.62) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL25363485 | 0.80 | ALOX5 (0.60) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL29832717 | 0.80 | ALOX5 (0.64) | ALOX5NFKB1NFKB2RELAOR51E2 | |
| SCHEMBL24510591 | 0.79 | ALOX5 (0.59) | ALOX5NFKB1NFKB2RELAOR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195323-B1 | Polyspirane compounds, use thereof in the treatment of malaria or toxoplasmosis and method for their preparation | UNIV JOSEPH FOURIER (FR) | 2011-12-28 | — | — | EP | disclosed |
| EP-2195323-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | Université Joseph Fourier (FR) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009077677-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2009-06-25 | — | — | WO | disclosed |