Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490990 | 0.87 | ALOX5 (0.69) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL27043019 | 0.86 | ALOX5 (0.59) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL2852406 | 0.84 | ALOX5 (0.70) | ALOX5CYP1A2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL20940489 | 0.83 | ALOX5 (1.00) | ALOX5CYP1A2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL25363485 | 0.81 | ALOX5 (0.60) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL28104847 | 0.81 | CYP3A4 (0.65) | ALOX5CYP1A2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL29832717 | 0.77 | ALOX5 (0.64) | ALOX5CYP1A2CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL14311297 | 0.77 | ALOX5 (0.56) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL6143465 | 0.77 | ALOX5 (0.56) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL17306533 | 0.76 | ALOX5 (0.55) | ALOX5NFKB1NFKB2RELATNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389569-B2 | Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same | UNIVERSITE JOSEPH FOURIER (FR) | 2013-03-05 | — | — | US | disclosed |
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | FLOT1, PHOSPHO1, GPAA1 | ALOX5 1649/4885CYP1A2 2026/4885CYP3A4 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.