Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26011209 | 0.98 | — | — | |
| SCHEMBL30917693 | 0.98 | — | — | |
| SCHEMBL26011205 | 0.98 | — | — | |
| SCHEMBL178545 | 0.98 | — | — | |
| SCHEMBL84792 | 0.98 | — | — | |
| SCHEMBL1086946 | 0.98 | — | — | |
| Bromide SCHEMBL7595850 | 0.95 | POLB (0.48) | POLBL3MBTL1CYP1A2CHRNB2CHRNA4 | |
| SCHEMBL7328192 | 0.93 | POLB (0.47) | POLBL3MBTL1CYP1A2CHRNB2CHRNA4 | |
| Lithium Ion SCHEMBL7328185 | 0.91 | POLB (0.45) | POLBL3MBTL1CYP1A2CHRNB2CHRNA4 | |
| SCHEMBL25262256 | 0.91 | CYP1A2 (0.55) | POLBL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112218845-A | FOXM1 inhibitor compositions and methods of use thereof | 伊利诺伊大学理事会 | 2021-01-12 | — | — | CN | claimed |
| CN-112218845-A | FOXM1 inhibitor compositions and methods of use thereof | 伊利诺伊大学理事会 | 2021-01-12 | — | — | CN | disclosed |