⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84792 | 1.00 | — | — | |
| SCHEMBL26011205 | 1.00 | — | — | |
| SCHEMBL26011209 | 1.00 | — | — | |
| SCHEMBL178545 | 1.00 | — | — | |
| SCHEMBL1086946 | 1.00 | — | — | |
| Bromide SCHEMBL7595850 | 0.98 | POLB (0.48) | — | |
| Iodide SCHEMBL28525835 | 0.98 | POLB (0.48) | — | |
| SCHEMBL7328192 | 0.95 | POLB (0.47) | — | |
| Lithium Ion SCHEMBL7328185 | 0.93 | POLB (0.45) | — | |
| SCHEMBL25262256 | 0.93 | CYP1A2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025245127-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-11-27 | — | — | WO | disclosed |
| EP-4622716-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| WO-2025064848-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-03-27 | — | — | WO | disclosed |
| WO-2025038936-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-02-20 | — | — | WO | disclosed |
| WO-2024112654-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-05-30 | — | — | WO | disclosed |