Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526234 | 1.00 | RIPK1 (0.44) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL29856167 | 0.92 | TSHR (0.42) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL20170496 | 0.84 | HSP90AA1 (0.56) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL22165572 | 0.83 | RIPK1 (0.47) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL29748129 | 0.83 | RIPK1 (0.47) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL23579324 | 0.83 | RIPK1 (0.47) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL28946625 | 0.83 | RIPK1 (0.46) | RIPK1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL28946605 | 0.83 | RIPK1 (0.46) | RIPK1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL2325712 | 0.82 | NR1H2 (0.57) | RIPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL6071600 | 0.82 | TSHR (0.55) | RIPK1TSHRALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490708-B | Sulfonamide macrocyclic derivative, preparation method and application thereof | 苏州亚盛药业有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-115490708-A | Sulfonamide macrocyclic derivatives, and preparation method and application thereof | 苏州亚盛药业有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |