Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | PPIG | Q13427 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31444419 | 1.00 | TSHR (0.55) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL20170496 | 0.86 | HSP90AA1 (0.56) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL23579324 | 0.85 | RIPK1 (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL22165572 | 0.85 | RIPK1 (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL29748129 | 0.85 | RIPK1 (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL9025358 | 0.85 | TSHR (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL9025348 | 0.85 | TSHR (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL9025370 | 0.85 | TSHR (0.47) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 | |
| SCHEMBL28961568 | 0.85 | ALDH1A1 (0.59) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL19174905 | 0.84 | RIPK1 (0.46) | TSHRHSP90AA1HSP90AB1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160794-A1 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160794-A1 | Tachykinin receptor antagonists | TACR1, TACR2, PROKR1 | TSHR 317/4885HSP90AA1 2007/4885HSP90AB1 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.