Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28538655 | 0.89 | KDM4E (0.37) | SMN1; SMN2HPGDLMNAKDM4ETSHR | |
| SCHEMBL23355371 | 0.79 | KDM4E (0.45) | SMN1; SMN2HPGDLMNAKMOKDM4E | |
| SCHEMBL21616262 | 0.77 | KDM4E (0.41) | SMN1; SMN2HPGDLMNAKDM4ETSHR | |
| SCHEMBL30203153 | 0.77 | KDM4E (0.41) | SMN1; SMN2HPGDLMNAKDM4ETSHR | |
| SCHEMBL28909804 | 0.74 | KMO (0.47) | SMN1; SMN2LMNAKMOKDM4EALDH1A1 | |
| SCHEMBL21612825 | 0.72 | KDM4E (0.42) | SMN1; SMN2HPGDLMNAKDM4ETSHR | |
| SCHEMBL23355373 | 0.71 | KDM4E (0.45) | SMN1; SMN2HPGDLMNAKDM4ETSHR | |
| SCHEMBL15117470 | 0.70 | MAPK14 (0.37) | HPGDLMNAKDM4ETSHRMAPK14 | |
| SCHEMBL1690753 | 0.69 | ESR2 (0.45) | MEN1KMT2A | |
| SCHEMBL23368213 | 0.69 | CYP17A1 (0.42) | SMN1; SMN2KDM4EMAPTTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112334460-A | Biaryl ether type quinazoline derivative | 第一三共株式会社 | 2021-02-05 | — | — | CN | disclosed |