Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526784 | 0.89 | SMN1; SMN2 (0.38) | KDM4ESMN1; SMN2TSHRGAAMAPK14 | |
| SCHEMBL28522620 | 0.80 | STIM1 (0.37) | DHODH | |
| SCHEMBL23355373 | 0.79 | KDM4E (0.45) | KDM4ESMN1; SMN2TSHRPOLBMAPK14 | |
| SCHEMBL23368213 | 0.76 | CYP17A1 (0.42) | KDM4ESMN1; SMN2POLBMAPTTHRB | |
| SCHEMBL30203277 | 0.76 | CYP17A1 (0.42) | KDM4ESMN1; SMN2POLBMAPTTHRB | |
| SCHEMBL21616259 | 0.75 | KDM4E (0.48) | KDM4ESMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL23355459 | 0.74 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2GAAPOLBNPC1 | |
| SCHEMBL28540608 | 0.71 | KDM4C (0.32) | MAPT | |
| SCHEMBL23355371 | 0.70 | KDM4E (0.45) | KDM4ESMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL15117470 | 0.69 | MAPK14 (0.37) | KDM4ETSHRMAPK14MAPK11HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112334460-A | Biaryl ether type quinazoline derivative | 第一三共株式会社 | 2021-02-05 | — | — | CN | disclosed |