Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406287 | 1.00 | TAAR1 (0.59) | TAAR1HTR2ATSHRCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL8120982 | 0.97 | TAAR1 (0.56) | TAAR1HTR2ATSHRCHRNB2CHRNA4 | |
| SCHEMBL4377946 | 0.80 | HRH1 (0.62) | TAAR1HTR2ATSHRCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL4374017 | 0.78 | HRH1 (0.60) | TAAR1HTR2ATSHRCHRNB2CHRNA4 | |
| SCHEMBL22042229 | 0.78 | TSHR (0.55) | TAAR1HTR2ATSHRHRH1DPP4 | |
| SCHEMBL9425022 | 0.78 | TSHR (0.55) | TAAR1HTR2ATSHRHRH1DPP4 | |
| SCHEMBL11460830 | 0.77 | TSHR (0.48) | TAAR1HTR2ATSHRHRH1SLC6A4 | |
| SCHEMBL3702383 | 0.77 | TSHR (0.48) | TAAR1TSHRSLC6A4SLC6A3GABBR2 | |
| SCHEMBL3317983 | 0.77 | TSHR (0.48) | TAAR1TSHRSLC6A4SLC6A3GABBR2 | |
| SCHEMBL3695940 | 0.77 | TSHR (0.48) | TAAR1TSHRSLC6A4SLC6A3GABBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250151-B | Preparation method of ambrisentan | 济南周行医药科技有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-108250151-B | Preparation method of ambrisentan | 济南周行医药科技有限公司 | 2021-03-16 | — | — | CN | disclosed |