Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GABBR2 | O75899 | 6/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317983 | 1.00 | TSHR (0.48) | TSHRMAPK1HIF1ATDP1GABBR2 | |
| SCHEMBL3695940 | 1.00 | TSHR (0.48) | TSHRMAPK1HIF1ATDP1GABBR2 | |
| SCHEMBL6398941 | 0.78 | TAAR1 (0.39) | TDP1LMNACYP1A2SMN1; SMN2CHRNA7 | |
| SCHEMBL1978520 | 0.77 | CHRNA7 (0.68) | TSHRGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL10507284 | 0.77 | GABBR2 (0.64) | TSHRMAPK1HIF1ATDP1GABBR2 | |
| SCHEMBL3406287 | 0.77 | TAAR1 (0.59) | TSHRGABBR2GABBR1CYP2C9CYP1A2 | |
| SCHEMBL3167744 | 0.77 | TSHR (0.50) | TSHRMAPK1HIF1ATDP1LMNA | |
| SCHEMBL28527237 | 0.77 | TAAR1 (0.59) | TSHRGABBR2GABBR1CYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL8120982 | 0.75 | TAAR1 (0.56) | TSHRGABBR2GABBR1SLC6A4SLC6A3 | |
| SCHEMBL1953110 | 0.75 | ADRB2 (0.52) | TSHRGABBR2GABBR1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2712865-B1 | Improved process for the preparation of ambrisentan | CADILA HEALTHCARE LTD (IN) | 2016-03-16 | — | — | EP | disclosed |
| US-8962832-B2 | Process for the preparation of ambrisentan and novel intermediates thereof | CADILA HEALTHCARE LIMITED (IN) | 2015-02-24 | — | — | US | disclosed |
| EP-2451786-B1 | IMPROVED PROCESS FOR THE PREPARATION OF AMBRISENTAN AND NOVEL INTERMEDIATES THEREOF | CADILA HEALTHCARE LTD (IN) | 2014-01-22 | — | — | EP | disclosed |
| US-20120184573-A1 | PROCESS FOR THE PREPARATION OF AMBRISENTAN AND NOVEL INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2012-07-19 | — | — | US | disclosed |
| EP-2451786-A2 | IMPROVED PROCESS FOR THE PREPARATION OF AMBRISENTAN AND NOVEL INTERMEDIATES THEREOF | Cadila Healthcare Limited (IN) | 2012-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184573-A1 | PROCESS FOR THE PREPARATION OF AMBRISENTAN AND NOVEL INTERMEDIATES THEREOF | ACVR1, ACVR1B, CYP11B1 | TSHR 2213/4885MAPK1 1319/4885HIF1A 2450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.