Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14258155 | 0.88 | BRAF (0.50) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2860656 | 0.87 | MAPT (0.41) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2852324 | 0.86 | MAPT (0.40) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2856122 | 0.84 | MAPT (0.39) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2859938 | 0.84 | MAPT (0.45) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2856296 | 0.83 | MAPT (0.38) | BRAFMAPTKEAP1NFE2L2KMT2A | |
| SCHEMBL2855798 | 0.83 | MAPT (0.45) | MAPTKEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL2858311 | 0.82 | RAB9A (0.47) | BRAFMAPTKMT2AMEN1NPC1 | |
| SCHEMBL2848615 | 0.82 | MAPT (0.44) | BRAFMAPTKMT2AMEN1POLB | |
| SCHEMBL2848317 | 0.82 | MAPT (0.46) | BRAFMAPTKEAP1NFE2L2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |