Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28515302 | 0.87 | L3MBTL1 (0.46) | L3MBTL1TDP1MAPTGRM2KDM4E | |
| SCHEMBL6004407 | 0.85 | KCNN4 (0.40) | L3MBTL1TDP1GRM2KDM4ECYP2C19 | |
| SCHEMBL28520016 | 0.78 | GABRA1 (0.34) | L3MBTL1TDP1 | |
| SCHEMBL16179018 | 0.76 | L3MBTL1 (0.41) | L3MBTL1TDP1GRM2KDM4ECYP1A2 | |
| SCHEMBL31394250 | 0.76 | L3MBTL1 (0.41) | L3MBTL1TDP1GRM2KDM4ECYP1A2 | |
| SCHEMBL29233757 | 0.76 | ALOX5AP (0.39) | L3MBTL1TDP1GRM2MAPK1SMN1; SMN2 | |
| SCHEMBL25235421 | 0.75 | L3MBTL1 (0.43) | L3MBTL1TDP1GRM2KDM4ECYP1A2 | |
| SCHEMBL4522678 | 0.75 | GRM2 (0.40) | L3MBTL1TDP1MAPTGRM2KDM4E | |
| SCHEMBL4535910 | 0.74 | L3MBTL1 (0.55) | L3MBTL1TDP1MAPTKDM4ELMNA | |
| SCHEMBL29234122 | 0.73 | GRM2 (0.42) | L3MBTL1TDP1GRM2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159405-B | Pyridopyrimidinone compounds and application thereof | 广州必贝特医药技术有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-112159405-A | Pyridopyrimidinone compounds and application thereof | 广州必贝特医药技术有限公司 | 2021-01-01 | — | — | CN | disclosed |