Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | OTC | P00480 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 5/20 | 0.34 |
| ▸ | NOS3 | P29474 | 4/20 | 0.34 |
| ▸ | NOS2 | P35228 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 3/20 | 0.32 |
| ▸ | ARG2 | P78540 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL29191149 | 0.95 | OTC (0.41) | GSROTCDDAH1NOS1NOS3 | |
| Arginine SCHEMBL28634978 | 0.94 | GSR (0.53) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL9393959 | 0.92 | GSR (0.46) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL460591 | 0.92 | GSR (0.56) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL8150773 | 0.90 | OTC (0.44) | GSROTCDDAH1NOS1NOS3 | |
| Arginine SCHEMBL355180 | 0.90 | OTC (0.44) | GSROTCDDAH1NOS1NOS3 | |
| Arginine SCHEMBL21816544 | 0.90 | GSR (0.57) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL15740622 | 0.90 | OTC (0.44) | GSROTCDDAH1NOS1NOS3 | |
| Arginine SCHEMBL29193380 | 0.90 | GSR (0.43) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL16637807 | 0.90 | OTC (0.37) | GSROTCDDAH1NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112522242-A | Application of Zika virus serine protease in removal of recombinant protein affinity tag | 广东省科学院生物工程研究所 | 2021-03-19 | — | — | CN | claimed |
| CN-112522242-A | Application of Zika virus serine protease in removal of recombinant protein affinity tag | 广东省科学院生物工程研究所 | 2021-03-19 | — | — | CN | disclosed |
| CN-112522242-A | Application of Zika virus serine protease in removal of recombinant protein affinity tag | 广东省科学院生物工程研究所 | 2021-03-19 | — | — | CN | disclosed |