Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | OTC | P00480 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.41 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27551474 | 0.95 | GSR (0.50) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL8957537 | 0.93 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL11660904 | 0.93 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL5698936 | 0.93 | OTC (0.49) | GSROTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL263652 | 0.93 | OTC (0.49) | GSROTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL6946785 | 0.93 | OTC (0.49) | GSROTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL1898345 | 0.93 | OTC (0.49) | GSROTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL3516723 | 0.93 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL20946267 | 0.93 | OTC (0.49) | GSROTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL15022773 | 0.93 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065131-A1 | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE | REVANCE THERAPEUTICS, INC. (US) | 2012-03-15 | — | — | US | disclosed |
| US-8022179-B2 | Compositions and methods for topical application and transdermal delivery of an oligopeptide | REVANCE THERAPEUTICS, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| EP-1856139-B1 | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE | REVANCE THERAPEUTICS INC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20090247464-A1 | Compositions and Methods for Topical Application and Transdermal Delivery of an Oligopeptide | REVANCE THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| EP-1856139-A2 | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE | Revance Therapeutics, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20070037252-A1 | Compositions and methods for topical application and transdermal delivery of an oligopeptide | REVANCE THERAPEUTICS, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| WO-2006094193-A2 | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE | REVANCE THERAPEUTICS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |