Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647181 | 0.89 | PDE10A (0.55) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL3839705 | 0.88 | PDE10A (0.54) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL28529940 | 0.87 | PDE10A (0.73) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL13870792 | 0.84 | PDE10A (0.49) | PDE10AALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL2125225 | 0.83 | PDE10A (1.00) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL28526038 | 0.83 | PDE10A (0.67) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL29678567 | 0.83 | PDE10A (0.67) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL27961602 | 0.83 | KDM4E (0.62) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL17942814 | 0.83 | ALDH1A1 (0.62) | PDE10AALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL13647118 | 0.82 | PDE10A (0.47) | PDE10AALDH1A1KDM4EL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112521333-A | Synthesis method of chiral 2, 3-disubstituted tetrahydroquinoline derivative | 中国科学院大连化学物理研究所 | 2021-03-19 | — | — | CN | disclosed |