Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 7/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28519199 | 0.85 | SMN1; SMN2 (0.55) | ADRB1GPR84SMN1; SMN2HTR1AADRA2A | |
| SCHEMBL26084592 | 0.84 | HTR2A (0.55) | ADRB3ADRB1ADRB2GPR84HTR1A | |
| SCHEMBL23100717 | 0.79 | ITGB2 (0.54) | SMN1; SMN2ITGB2ICAM1ITGALKDM4E | |
| SCHEMBL23100719 | 0.79 | ITGB2 (0.54) | SMN1; SMN2ITGB2ICAM1ITGALKDM4E | |
| SCHEMBL28547399 | 0.78 | CDK4 (0.48) | ADRB1GPR84SMN1; SMN2HTR1AADRA2A | |
| SCHEMBL28547398 | 0.78 | CDK4 (0.48) | ADRB1GPR84SMN1; SMN2HTR1AADRA2A | |
| SCHEMBL9279873 | 0.74 | SMN1; SMN2 (0.68) | ADRB1GPR84SMN1; SMN2HTR1AADRA2A | |
| SCHEMBL30911955 | 0.74 | SSTR3 (0.58) | SMN1; SMN2MAPTPOLBTSHR | |
| SCHEMBL28528875 | 0.73 | MGAM (0.51) | GPR84SMN1; SMN2SLC6A2SLC6A4MAPT | |
| SCHEMBL7214546 | 0.73 | CNR2 (0.53) | SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112250614-B | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2022-02-01 | — | — | CN | disclosed |
| CN-112250614-A | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2021-01-22 | — | — | CN | disclosed |