Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 9/20 | 0.51 |
| ▸ | GAA | P10253 | 9/20 | 0.51 |
| ▸ | SI | P14410 | 9/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348944 | 0.85 | MGAM (0.64) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL28519198 | 0.85 | MEN1 (0.66) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL22922613 | 0.81 | MAPT (0.52) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL5186684 | 0.74 | CYP2D6 (0.67) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL31232965 | 0.74 | MGAM (0.67) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL7091761 | 0.74 | TDO2 (0.46) | GPR84SLC6A4KCNH2 | |
| SCHEMBL7967556 | 0.73 | GPR84 (0.62) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL28528876 | 0.73 | ADRB3 (0.54) | GPR84KMT2AMEN1POLBSLC6A2 | |
| SCHEMBL14168804 | 0.71 | GPR84 (0.64) | MGAMGAASIMGAM2GPR84 | |
| SCHEMBL27358106 | 0.71 | ALDH1A1 (0.55) | MGAMGAASIMGAM2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112250614-B | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2022-02-01 | — | — | CN | disclosed |
| CN-112250614-A | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2021-01-22 | — | — | CN | disclosed |