Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18304994 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL30806393 | 0.87 | KMT2A (0.42) | ALDH1A1KMT2AMEN1ABCB1ABCC1 | |
| SCHEMBL28082067 | 0.87 | KMT2A (0.42) | ALDH1A1KMT2AMEN1ABCB1ABCC1 | |
| SCHEMBL30806384 | 0.87 | KMT2A (0.42) | ALDH1A1KMT2AMEN1ABCB1ABCC1 | |
| SCHEMBL28082066 | 0.87 | KMT2A (0.42) | ALDH1A1KMT2AMEN1ABCB1ABCC1 | |
| SCHEMBL18128029 | 0.87 | SRD5A2 (0.39) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL20138082 | 0.87 | SRD5A2 (0.39) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL28463373 | 0.85 | MAPT (0.38) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL28457435 | 0.85 | MAPT (0.38) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL28457438 | 0.85 | MAPT (0.38) | ALDH1A1KMT2AMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561561-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | Septerna, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024026076-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | SEPTERNA, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |