Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12381737 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL30843796 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL7919861 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL8869835 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL9308794 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL8566009 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL16022317 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL18210040 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL25594206 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL25594208 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112430235-B | PF-06651600 middle Process for the preparation of a body | 东莞市东阳光仿制药研发有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-112430208-A | Preparation method of PF-06651600 intermediate | 东莞市东阳光仿制药研发有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-112430235-A | Preparation method of PF-06651600 intermediate | 东莞市东阳光仿制药研发有限公司 | 2021-03-02 | — | — | CN | disclosed |