Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12381737 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL30843796 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL28529567 | 1.00 | KMT2A (0.60) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL8869835 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL9308794 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL8566009 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL16022317 | 0.89 | KMT2A (0.61) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL18210040 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL25594206 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB | |
| SCHEMBL25594208 | 0.86 | KMT2A (0.58) | KMT2AL3MBTL1DRD2KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759535-B | Preparation method of PF-06651600 intermediate | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-115894338-B | Method for preparing Ritlecritinib intermediate by chemical-biological enzyme coupling | 华南理工大学 | 2024-02-13 | — | — | CN | disclosed |
| CN-115894338-A | Method for preparing Ritlecetinib intermediate by coupling chemical enzyme and biological enzyme | 华南理工大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-112759535-A | Preparation method of PF-06651600 intermediate | 广东东阳光药业有限公司 | 2021-05-07 | — | — | CN | disclosed |
| US-8710076-B2 | 2,5-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710076-B2 | 2,5-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20110201632-A1 | 2,5-Disubstituted Piperidine Orexin Rceptor Antagonists | MERCK SHARP & DOHME LLC | 2011-08-18 | — | — | US | disclosed |
| WO-2010048012-A1 | 2,5-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201632-A1 | 2,5-Disubstituted Piperidine Orexin Rceptor Antagonists | HCRTR2, HCRTR1, CRHR2 | KMT2A 846/4885L3MBTL1 4615/4885DRD2 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.