Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 6/20 | 0.55 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7997152 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL538792 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL9135671 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL11307248 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL15420047 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL11316678 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL7504887 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL19347055 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL9481330 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL10592361 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102428987-A | Preparation method of flour food | WUJIANG WHUA HARDWARE PRODUCTS CO LTD | 2012-05-02 | — | — | CN | claimed |
| EP-1244779-A1 | SUBTILASE VARIANTS HAVING AN IMPROVED WASH PERFORMANCE ON EGG STAINS | Novozymes A/S (DK) | 2002-10-02 | — | — | EP | claimed |
| WO-2001044452-A1 | SUBTILASE VARIANTS HAVING AN IMPROVED WASH PERFORMANCE ON EGG STAINS | NOVOZYMES A/S (DK) | 2001-06-21 | — | — | WO | claimed |
| US-11859221-B2 | Enzyme variants and polynucleotides encoding the same | NOVOZYMES A/S (DK) | 2024-01-02 | — | — | US | disclosed |
| EP-3452497-A1 | ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | Novozymes A/S (DK) | 2019-03-13 | — | — | EP | disclosed |
| EP-3397761-A1 | ENZYME VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | Novozymes A/S (DK) | 2018-11-07 | — | — | EP | disclosed |
| WO-2017191160-A1 | ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | NOVOZYMES A/S (DK) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017114891-A1 | ENZYME VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | NOVOZYMES A/S (DK) | 2017-07-06 | — | — | WO | disclosed |
| CN-101932703-B | There is the alpha-amylase variants of the characteristic of change | DANISCO US INC. (US) | 2015-08-05 | — | — | CN | disclosed |
| CN-101848985-B | Variants of bacillus sp. TS-23 alpha-amylase with altered properties | DANISCO US INC | 2014-12-03 | — | — | CN | disclosed |
| CN-101848986-B | Alpha-amylase variants with altered properties | DANISCO US INC | 2014-12-03 | — | — | CN | disclosed |
| EP-0910631-A2 | ENZYME-CONTAINING GRANULES AND PROCESS FOR THE PRODUCTION THEREOF | NOVO NORDISK A/S (DK) | 1999-04-28 | — | — | EP | disclosed |
| EP-0894128-A1 | CONJUGATION OF POLYPEPTIDES | NOVO NORDISK A/S (DK) | 1999-02-03 | — | — | EP | disclosed |
| EP-0851913-A1 | NOVEL LIPOLYTIC ENZYMES | NOVO NORDISK A/S (DK) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997039116-A1 | ENZYME-CONTAINING GRANULES AND PROCESS FOR THE PRODUCTION THEREOF | NOVO NORDISK A/S (DK) | 1997-10-23 | — | — | WO | disclosed |
| EP-0796324-A1 | POLYPEPTIDE WITH REDUCED ALLERGENICITY | NOVO NORDISK A/S (DK) | 1997-09-24 | — | — | EP | disclosed |
| WO-1997030148-A1 | CONJUGATION OF POLYPEPTIDES | NOVO NORDISK A/S (DK) | 1997-08-21 | — | — | WO | disclosed |
| WO-1997007202-A1 | NOVEL LIPOLYTIC ENZYMES | NOVO NORDISK A/S (DK) | 1997-02-27 | — | — | WO | disclosed |
| WO-1996040791-A1 | MODIFICATION OF POLYPEPTIDES | NOVO NORDISK A/S (DK) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996017929-A1 | POLYPEPTIDE WITH REDUCED ALLERGENICITY | NOVO NORDISK A/S (DK) | 1996-06-13 | — | — | WO | disclosed |